Location: Route 21 and Route 110, Jefferson Cty Reassurance shield after the 110 junction. Location: Route 21 and Route 110, De Soto A couple hundred feet later, we’ll enter De Soto. 21 clips the west edge of town only. Location: Route 21 and Route Y, De Soto In De Soto, we’ll approach Route Y. Location: … Continue reading Missouri Route 21, MO-110 to MO-104